Evidence Based Research | Patient Resources

Squamous cell carcinoma (SCC) is one of the most common cancers of the head and neck region worldwide and is generally treated surgically in combination with radiotherapy and/or chemotherapy. However, anticancer agents have numerous serious side effects, and alternative, less toxic agents that are effective as chemotherapeutics for SCC are required. The Paeoniaceae family is widely used in traditional Chinese medicine. We examined methanol and butanol extracts of Paeonia lutea ( P. lutea ) le...

In weight gain, increased adiposity is accompanied by accelerated aging of fat tissue. This change is most marked in visceral adipose, where it cultivates a specific array of inflammatory changes that enable these fat cells to survive under disadvantageous conditions. With the expansion of fat tissue, this pattern of altered cytokine production is known as a “senescence-associated secretory phenotype,” or SASP. In adipose, having a SASP affects immune homeostasis and energy meta...

Chimeric antigen receptor (CAR) T-cell therapy has the potential to replace chemoimmunotherapy for second-line treatment of patients with large B-cell lymphoma (LBCL) that have relapsed or are refractory to first-line therapy, results of the phase 3 ZUMA-7 and TRANSFORM trials suggest. In the ZUMA-7 trial, at a median follow-up of 24.9 months, patients randomly assigned to receive CAR T-cell therapy with axicabtagene ciloleucel, or axi-cell (Yescarta) had a median event-free survival (EFS) o...

Numerous studies have shown that coffee drinking is associated with a lower risk of dying from all causes of death. However, associations with cancer overall or with specific types of cancer are unclear. In 2016, an expert working group convened for the International Agency for Research on Cancer Monographs Programme reviewed the world’s body of human and laboratory research on coffee drinking and cancer risk, and they found evidence of carcinogenicity of coffee drinking to be “...

The papaya or pawpaw (Carica papaya) is a tropical fruit, which has been consistently associated with numerous medicinal properties. One of the most important of these claims is the ability of papaya leaf extract to revert low platelet counts to normal in dengue fever. Several researchers have tested preparations of papaya leaf, in particular, in regard to the platelet count. One systematic review confirmed the increase in platelet count to be more significant in the group that received the...