Evidence Based Research | Patient Resources

Studies have shown that the gut microbiota could influence the response of melanoma to anti–PD-1 immunotherapy. It is known that only 30%-40% of melanoma patients respond to anti–PD-1 immunotherapy, so the researchers focused on the gut microbiota of adult male patients. For the study, which was funded by the National Institutes of Health and published in Science, Professor Zarour and a team of colleagues, including Dr Diwakar Davar, MD, a Medical Oncologist/haematologist at...

Follicular lymphomas (FL) are a type of non-Hodgkin’s lymphomas that most times respond very well to chemotherapy treatments (first-line therapy). Follicular lymphoma are associated with the over expression of Bcl-2 and chromosomal translocation (14;18), leading to deregulated apoptosis. As Bcl-2 is an important negative regulator of the mitochondrial pathway, novel therapeutic approaches circumventing the mitochondrial block may prove useful to treat these patients. A few unconve...

In industrialised countries, modern diets provide an abundance of omega-6 polyunsaturated fats (PUFAs) relative to omega-3 PUFAs, and this is known to contribute to the incidence of cardiovascular conditions along with the chronic immune activation seen in atopic and inflammatory disorders. Nutrition research has shown that an intervention as simple as increasing dietary intakes of EPA and DHA relative to common omega-6 fats could effectively improve cardiovascular outcomes in individuals an...

Mitochondria are now recognised beyond their role as the cell’s “powerhouse”. A systematic review on the mitochondria in psychological stress describes the mitochondria as subcellular organelles that sustain life through energy transformation and intracellular signalling, with research showing mitochondria changes directly impact systemic metabolic regulation, brain function, immunity, ageing and life-span. Emerging research further supports the important role of the mitoc...

The nucleus of a cell fills a crucial function: to protect cell DNA and enable its proper use. But it can be deformed, or even temporarily fractured, if the cell itself is compressed and deformed, for example, in the case of migration or proliferation. This compression then leads to DNA damage. The consequences are accelerated ageing for healthy cells and the acquisition of invasive properties for breast tumour cells, as has just been shown by a research team from CNRS, Institut Curie and I...