Tumor Microenvironment in Ovarian Cancer
For a long time, cancer stroma has been considered as a passive by-stander in carcinogenesis, subjected to modification associated with the reactive inflammation. It is now recognized that the vascularization and the cellular composition of the tumor microenvironment influence the development and progression of ovarian cancer by controlling the availability of nutrients, oxygen, growth factors, and inflammatory and immune-regulatory soluble factors that ultimately impinge on autophagy regulation in cancer cells.
In ovarian cancer, the stroma can either hamper or sustain the proliferation and spread of these cells. Hence, targeting cancer microenvironment could be an effective therapeutic strategy to limiting ovarian cancer aggressiveness and relapse.
Increasing lines of evidence suggest that a consistent and prolonged amino acid starvation in ovarian cancer cells modulates the microenvironment. The same is demonstrated with therapeutic doses of bioavilable resveratrol.
Ferraresi A, Titone R, Follo C, Castiglioni A, Chiorino G, Dhanasekaran DN, et al. The protein restriction mimetic Resveratrol is an autophagy inducer stronger than amino acid starvation in ovarian cancer cells. Mol Carcinog (2017) 56(12):268191. doi: 10.1002/mc.22711
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