Posted in Pathways
Posted by Manuela Boyle on 14 June 2021
Metabolic reprogramming is a major hallmark of cancer, which is characterized by upregulated glycolysis, glutaminolysis, lipid metabolism, pentose phosphate pathway, mitochondrial biogenesis, among others. These metabolic programs provide cancer cells with not only energy but also vital metabolites to support large-scale biosynthesis, continuous proliferation and other major processes of tumorigenesis. Potent oncogenes as c-Myc, HIF1, Ras and PI3K/Akt are important promoters of cancer meta...
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