Posted by Manuela Boyle on 24 April 2021
Diindolymethane (DIIM) is a metabolite generated when the stomach breaks down Indole-3-Carbinol (I3C) found in cruciferous vegetables like broccoli, kale, bok choy, cabbage, cauliflower, collards, kale, Brussels sprouts, and kohlrabi. Once consumed, the bioactive constituents are rapidly metabolized into several intermediate and end products.  As an antioxidant, this phytonutrient has shown to promote healthy oestrogen metabolism in both men and women. An appropriate oestrogen metabolism optimises the ratios of oestrogen but also progesterone and testosterone in the body. In order to get the recommended daily amount of DIIM, one would have to consume at least 1 kilogram of these vegetables daily. This is the reason why we recommend supplementation.

Thomson, C. A., Ho, E., & Strom, M. B. (2016). Chemopreventive properties of 3,3'-diindolylmethane in breast cancer: evidence from experimental and human studies. Nutrition reviews, 74(7), 432443. https://doi.org/10.1093/nutrit/nuw010

Author: Manuela Boyle
Tags: News Nutritional Supplements Evidence Based Research Cancer Breast Cancer foods & cancer treatment


  • The Institute for Functional Medicine
  • Society for Integrative Oncology
  • American Society of Clinical Oncology
  • Australasian Integrative Medicine Association
  • Naturopaths and Herbalists Association of Australia
  • British Naturopathic Association

Disclaimer: Manuela Boyle is not a registered medical practitioner or specialist medical oncologist. Manuela Boyle is a general health service provider who is not legally required to be registered under National Health Practitioner regulation law. She practises under the national Code of Conduct that sets standards to general health service providers who are not regulated by the Australian Health Practitioner Regulation Agency.

Manuela Boyle is an accredited member of the following professional organisations:
NHAA (Naturopaths & Herbalists Association of Australia), SIO (Society of Integrative Oncology) USA, AIMA (Australasian Integrative Medical Association), IFM (Institute of Functional Medicine) USA