Inflammation meets cancer, with NF-κB as the matchmaker

Posted on 22 September 2020

Inflammation meets cancer, with NF-kB as the matchmaker is an article from Nature Immunology.

"Inflammation is a fundamental protective response that sometimes goes awry and becomes a major cofactor in the pathogenesis of many chronic human diseases, including cancer. Here we review the evolutionary relationship and opposing functions of the transcription factor NF-kB in inflammation and cancer. Although it seems to fulfill a distinctly tumor-promoting role in many types of cancer, NF-kB has a confounding role in certain tumors. Understanding the activity and function of NF-kB in the context of tumorigenesis is critical for its successful taming, an important challenge for modern cancer biology."

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