Inflammasone has a relationship with obesity-related colon cancer.
According to recent evidence-based research, dysregulation of inflammasomes could be a significant factor in the development of obesity-associated colon cancer. When this part of the innate immune system, which provides the first line of defence against pathogens, is exposed to prolonged inflammation from visceral adipose tissue (VAT), it increases the risk of obesity-related colon cancer.
Dysregulation of inflammasomes within VAT (the fat that surrounds the organs) and in the colon can trigger prolonged episodes of inflammation, increasing the risk for colon cancer. The aim of this study was to explore whether obesity and colon cancer influence the expression of different inflammasomes and their main 'trigger' molecules (called interleukins 1-beta and 18), in VAT and in the colon, where they could create a microenvironment favourable for tumour growth.
The study was conducted at the University Hospital Navarra and CIBEROBN, Instituto de Salud Carlos III, Pamplona, Spain. It was carried out on the tissue samples were obtained from 99 subjects: 38 people were lean, and 61 people were obese. The study revealed for the first time that obesity increase gene expression levels of the proteins NLRP3, NLRP6, ASC, IL1B and NOD2 in VAT. It was also found that obese people had a reduced level of adiponectin and consequently less insulin sensitivity.
The team also found evidence of a possible role for inflammasomes in altering the expression levels of proteins involved in maintaining the integrity of the intestinal wall.
A healthy diet that is rich in anti-inflammatories together with appropriate lifestyle changes can reduce obesity and associated risks.
Catalán V Tissue-specific functions of the inflammasomes in colon cancer development in an obesity context TS02.01 Presented at: European Association for the Study of Obesity (EASO) 28th European Congress on Obesity, held May 10 13, 2021.
[Guo H, Callaway JB, Ting JP. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med. 2015 Jul;21(7):677-87. doi: 10.1038/nm.3893. Epub 2015 Jun 29. PMID: 26121197; PMCID: PMC4519035.
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