Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer
Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer is an article from Biochim Biophys Acta Rev Cancer.
"The idea of using known and approved drugs for new indications has recently gained considerable momentum in many fields of medicine, especially in complex disorders. This approach presents an important advantage, as compared to the "de novo" drug discovery process, by considerably reducing the cost and time to bring a new treatment to patients. Drug repurposing, a term also referred to as repositioning or redirection, might be compared to giving a new use to an existing tool that already comes with a technical handbook: repurposed drugs have well-documented toxicity, pharmacology and drug-drug interaction parameters. Moreover, rescuing drugs that failed in one indication can deliver a potential drug candidate to another. The current status of drug repurposing is collected in the reproDB site (http://apps.chiragjpgroup.org/repoDB/). It is encouraging that the EMA in Europe, as well as the NIH and the FDA in the USA have already launched drug repurposing programs to identify new uses for existing pipeline medications developed by the pharmaceutical industry."